amidepsine A Property

Boiling point:

773.3±60.0 °C(Predicted)

Density 

1.356±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in methanol

form 

Pale white to pale yellow powder.

pka

3.53±0.10(Predicted)

color 

Pale white

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P501Dispose of contents/container to..…

amidepsine A Chemical Properties,Usage,Production

Uses

Amidepsine A is a fungal metabolite, isolated from the culture broth of Humicola sp. FO-2942 that inhibits DGAT activity.

Biological Activity

amidepsine a is a fungal metabolite isolated from the culture broth of humicola sp fo-2942. amidepsine a is an inhibitor of dylglycerol acyltransferase (dgat).dylglycerol acyltransferase (dgat) has been involved in catalyzing the formation of triglycerides from diacylglycerol and acyl-coa. the reaction is considered the terminal and only committed step in triglyceride synthesis and is essential for the formation of adipose tissue. there are two isozymes of dgat have been identified: dgat1 and dgat2. dgat-1 deficient mice are lean and resistant to the development of diet-induced obesity or insulin resistance [1]. dgat2-/- mice demonstrate reduced triglyceride levels and suffer from skin barrier abnormalities [2].fo-2942 inhibited dgat activity with an ic50 of 10.2 μm in rat liver microsomes. fo-2942 inhibited triacylglycerol formation in raji cells with the ic50 value of 15.5 μm [1].

storage

+4°C

References

[1] tomoda h, tabata n, ito m, et al. amidepsines, inhibitors of diacylglycerol acyltransferase produced by humicola sp. fo-2942[j]. the journal of antibiotics, 1995, 48(9): 942-947.
[2] smith s j, cases s, jensen d r, et al. obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking dgat[j]. nature genetics, 2000, 25(1): 87-90.
[3] stone s j, myers h m, watkins s m, et al. lipopenia and skin barrier abnormalities in dgat2-deficient mice[j]. journal of biological chemistry, 2004, 279(12): 11767-11776.